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Background: Maternal Mortality Ratio (MMR) of India for the period 2016-18, as per the latest report of the national Sample Registration system (SRS) data is 113/100,000 live births. Total estimated annual maternal deaths declined from 33800 maternal deaths in 2016 to 26437 deaths in 2018. The Government of India has been focusing on initiatives to improve maternal health indicators. Thus, the screening of high-risk pregnancy is a best strategy to improve knowledge and skill among nurses working in maternity unit to reduce MMR and maternal morbidity. Aim of the study is "A study to assess the effect of hands on training on Knowledge and Skill regarding Screening of High-Risk Pregnancy among the Nurses of selected Maternity unit in urban area." Materials and Method: A pre-experimental study method was undertaken where 60 nurses working in selected maternity unit in urban area were recruited as sample by non-probability convenient sampling method. Using knowledge questionnaire for knowledge 25 questions and skill 156 by observation checklist. After collection of data, it analysed using both descriptive and inferential statistics to describe and show the association between the variables Result: The 't in the pre-test the mean of the knowledge score obtained by the Nurses was 16.56 and in the post test it rise to 21.30. The knowledge score of the Nurses shows marked improvement after giving Hands on training. It is evident that the calculated 't' value is greater than the table value of 't' (2.05) at 0.05 level. This indicates that Hands on training is effective in improving the knowledge of the Nurses. Hence H0 is rejected and H1 is accepted. There is a significant improvement in scores from pre to post test at 5 % level i.e., p Conclusion: The high-risk pregnancy increases the burden of maternal morbidity and mortality, to reduce the MMR early detection and screening of High-Risk Pregnancy is one of the strategies. This study finding highlights that the Hands-on Training improves the knowledge and skill regarding Screening of High-Risk Pregnancy among the nurses. Thus, hands on training regarding high-risk pregnancy is effective method to improve knowledge and skill. The competent nurses by doing the early detection and Screening of High-Risk Pregnancy achieve the Sustainable Developmental Goal MMR