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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
DEVELOPMENT AND EVALUATION OF A BUCCAL DRUG DELIVERY SYSTEM FOR THE ANTI-ANGINAL DRUG-NICORANDIL
Authors
Sunil Firangi, Mashkura Sultana, R.B.Sangoligi, Dr Syed Sanaullah
Keywords
Nicorandil, Buccal tablet, Bio adhesive polymers, Zero order release kinetics.
Abstract
The aim of the present study was to develop buccal formulation of Nicorandil to maintain constant therapeutic levels of the drug for over period of 8hrs. Nicorandil dose was fixed as 3mg & total weight of the tablet was kept constant as 100mg.various bioadhesive polymers such as Carbopol 934 (CP), Polyvinylpyrrolidone (PVP), Polyvinylalcohol (PVA) and Ethylcellulose (EC), are used. All the formulations were passed by various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired release pattern i.e.,87.83 in 8hrs and maximum drug release due to high wettability of the polymer PVP and PVA. It followed zero order release kinetics mechanism.
IJCRT's Publication Details
Unique Identification Number - IJCRT2310478
Paper ID - 245441
Page Number(s) - e260-e268
Pubished in - Volume 11 | Issue 10 | October 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Sunil Firangi, Mashkura Sultana, R.B.Sangoligi, Dr Syed Sanaullah, "DEVELOPMENT AND EVALUATION OF A BUCCAL DRUG DELIVERY SYSTEM FOR THE ANTI-ANGINAL DRUG-NICORANDIL", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 10, pp.e260-e268, October 2023, Available at :http://www.ijcrt.org/papers/IJCRT2310478.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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