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ABSTRACT Phytotherapeutic plants have been the main source of raw ingredients for the treatment of a wide range of ailments, since ancient times. In order to maintain a healthy lifestyle and manage illnesses, many people rely on medicinal plants. Ethnomedicinal plant Clematis zeylanica (L.) Pori. also known as Naravelia zeylanica (Linn) DC., belonging to the family ranunculaceae is used in the Indian ayurvedic medicinal system. Helminthiasis, dermatopathy, leprosy, rheumatalgia, odontalgia, colic inflammation, wounds, and ulcers are just a few of the conditions it helps treat. The purpose of the current study was to assess the photochemical and biological characteristics of Clematis zeylanica. The photochemical composition of the ethanol extract of leaves and flowers was examined using Gas chromatogram-Tandem Mass Spectrometry (GC-MS/MS). The ethanol extract of Clematis zeylanica leaves and flowers was subjected to GC-MS/MS analysis and identified 31 and 29 bioactive chemical compounds, respectively. n-Hexadecanoic acid (22.98%), Linoleic acid ethyl ester (9.69%), 9,12,15-Octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (6.94%), and 9,12,15-Octadecatrienoic acid, (Z,Z,Z)- (6.76%), Geranyl palmitoleate (4.30%) make up the majority of the bioactive components in leaves. 3,7,11,15-tetramethylhexadec-2en-1-yl acetate (8.52%), (Tanshinone IIA) Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl- (5.84% +3.48% +5.36%), and beta-Tocopherol, O-methyl- (2.58%) are the principal bioactive chemicals found in flowers. This study reports compounds 9,12,15-Octadecatrienoic acid, ethyl ester, (Z,Z,Z)-, 9,12,15-Octadecatrienoic acid, (Z,Z,Z), Linoleic acid ethyl ester, Phenanthro[1,2-b]furan-10,11-dione, Geranyl palmioleate, Squalene as important new lead compounds for the first time from this species. Additional research is required to identify the extract's active ingredient and to clarify the precise mechanism of action in treating various illnesses and develop novel drugs.