Published Paper Details:

Aluminium fluoride is widely found in our nature and exposed to them via water, food, soil and contaminated air. It was also suggested that Al toxicity can induce pathological disorders such as hepatotoxicity, gastrointestinal and bone disease. Aluminium is non essential and fluoride is an essential trace element, but fluoride excessive intake can damage skeletal and non skeleton system. Its hepato-renal effects are well recorded but effects on total proteins, albumin and A/G ratio are poorly studied and this the soul of this work. Aloe vera plants are widely used to prevent several diseases. It has anti-tumor, anti-oxidant, anti-inflammatory and laxative properties. Aloe vera plant has been used for around hundred years in cosmetic product and pharmaceutical purpose. Ninety mature male of albino rats weight about 150-200gm were divided into two groups contained 30 rats each. The Ist group act as a control group (received only normal diet and water); the IInd group is treated group, A-group treated by AlF3 200mg/kg b. w. and B-group treated by AlF3+Aloe vera 300mg/kg .b w. had given by orally for one months. The results indicated significant increase in total protein, and decreased significantly albumin and A/G ratio after 30 days when compared to the control group animals and liver damage after its consumption in rats, which can be avoidable by antioxidants. The treatment with Aloe vera combined with AlF3 improved the backs mentioned biochemical alterations induced by AlF3. This study demonstrated that the combination of Aloe vera plant extract with AlF3 alleviated the toxic effects of AlF3. The Aloe vera plants has protective influences on the liver (hepatorenal) functions and it able to resist AlF3 intoxication.