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Abstract: Background: Bodybuilding is a challenging and demanding sport. Bodybuilding can provide a lot of excitement and a real sense of achievement. Bodybuilders can experience euphoria if they achieve a personal record for a particular lift or if they reach a milestone in their training. Overtraining can leave bodybuilders exhausted and feeling low in energy. If this continues for too long they will start to feel depressed. This can happen to any bodybuilder when you do not get in enough rest and sleep. Hence the focus of this study was to evaluate the effectiveness of self instructional module on Prevention of anxiety and depression among bodybuilders at selected bodybuilding training centers, Bengaluru, Karnataka.objectives:1.To assess the existing level of knowledge on prevention of anxiety and depression among body builders at selected body building training centers.2.To assess the post test level of knowledge on prevention of anxiety and depression among body builders at selected body building training centers.3.To evaluate the effectiveness of Self Instructional Module on knowledge regarding prevention of anxiety and depression among bodybuilders by comparing the pre and post-test knowledge score.4.To determine the association between pre-test knowledge scores of bodybuilders regarding prevention of anxiety and depression with their selected demographic variables.Research Design:Research design is an overall plan for addressing research questions including specification for enhancing the study integrity 31. In the present study the Quasi experimental design with one group pre test post test was adapted to assess the knowledge of bodybuilders at selected bodybuilding training centers, Bengaluru regarding the Prevention of anxiety and depression.Major findings of the study:Majority 90% of the bodybuilders had inadequate knowledge and 10% had moderate knowledge in the pretest. After administration of self instructional module 26.7% of the subjects had adequate knowledge, 63.3% had moderate knowledge and only 10% had inadequate knowledge regarding Prevention of anxiety and depression in the post test.The overall analysis of level of knowledge of bodybuilders regarding Prevention of anxiety and depression showed that mean knowledge scores of the subjects at pre-test were 11.93 (45.88%) found to be inadequate knowledge regarding Prevention of anxiety and depression. After administration of self instructional module mean knowledge scores of the subjects was 17.85 (68.65%) found to be improvement in the level of knowledge among bodybuilders.Conclusion:Findings of the study show that there was a significant difference in pre test and post test level of knowledge of bodybuilders. From this it is concluded that the self instructional module is effective in improving the level of knowledge of bodybuilders. And there was a significant association between level of knowledge of bodybuilders and selected demographic variables such as age and source of information.