Published Paper Details:

Aqueous solubility of API's has critical role in drug dissolution or availability of drug at the site of action or bioavailability, when a dosage form is administered orally. The fact that about 90 % of newly discovered API's or new molecular entity(NME) have little or no water solubility, presents a serious challenge to t he successful development & commercialization of new drugs in the pharmaceutical industry. Numerous techniques are available for the solubility enhancement but all individual techniques have its own limitations for commercialization. Micronization technique can reduce the particle size of material, which reduces particles down to the micrometer or nanometer size and increases the dissolution rate of drugs through increasing particle surface area, accelerating dissolution rates and ultimately improves the bioavailability of poorly soluble APIs. Micronization of poorly water-soluble drugs can be performed by Air Jet Mill or Ball Mill.