Published Paper Details:

The chase to improve the quality of life has stimulated desirable changes in research to design and develop a new drug and enhance its safety and effectiveness. Thus, there is a gradual rise in demand to develop susceptible and specific analytical techniques for newly developed drugs. Thus, analysts are striving very hard to develop new and efficient analytical methods to achieve these targets. The antiretroviral agents Rilpivirine (RPV) and cabotegravir (CAB) are approved as a combined treatment regimen against human immunodeficiency virus (HIV). This review article represents the collection and discussion of various analytical methods available in the literature for the estimation of the CAB and RPV in pharmaceutical formulations and biological samples consisting of HPLC, UPLC and hyphenated techniques such as LC-MS, LC-MS/MS. Moreover, we discuss about CAB and RPV chemical structure, mechanism of action, activity against drug-sensitive and -resistant HIV, and pharmacodynamics/pharmacokinetics properties. The present review can be effectively explored to conduct future analytical investigation for the estimation of Cabotegravir and Rilpivirine.