Published Paper Details:

Aim: The present study aimed to investigate the toxicity and oral glucose tolerance test (OGTT) of Leucomeris spectabilis leaves hydroalcoholic extract and flavonoid on albino Wistar rats. Methods: Both were prepared and administered orally to experimental animals. The extract was tested for toxicity in rats at a dose of 1,000 and 2000 mg/kg and flavonoid at a dose of 5, 50, 300, and 1500 mg/kg body weight p.o. The hypoglycemic effects of both normal rats and orally glucose-induced hyperglycemic rats were compared with distilled water and glibenclamide. The blood glucose level was obtained by pricking the tail vein using a glucometer at times -30, 0, 30, 60, 120, and 240 minutes. Results: The dose of hydroalcoholic extract and flavonoid did not exert any sign or symptom of toxicity and the dead rat was not found. The body weight and food consumption were significant. The blood glucose levels of hydroalcoholic extract and flavonoid-treated groups were not different from control and Glybenclamide treated. Conclusion: The findings of the present study can be concluded that the hydroalcoholic extract and flavonoid are practically non-toxic at a lower dose.