Published Paper Details:

Preformulation refers to a collection of research that concentrate on a novel drug candidate's physicochemical characteristics that might influence the drug's performance and the creation of a dosage form. This can support the necessity for molecular change or offer crucial information for formulation design. Before developing a pharmaceutical formulation, consideration was given to each drug's inherent chemical and physical qualities. This characteristic offers a framework for combining medications with pharmaceutical components to create dosage forms. The goal of the preformulation study is to create a dosage form that is beautiful, stable, safe, and effective by determining the kinetic rate profile, compatibility with other ingredients, and physico-chemical parameters of new therapeutic compounds. Drug solubility, partition coefficient, dissolving rate, polymorphic forms, and stability are among these qualities, and they all play significant roles in preformulation studies. The drug molecule's polymorphism, which includes crystal and amorphous forms, reveals many chemical, physical, and medicinal descriptions. This article describes a few characteristics and methods for medication preformulation evaluation parameters.