Published Paper Details:

Reactive oxygen species (ROS)-mediated diseases, characterized by oxidative stress and inflammation, pose significant challenges in the field of medicine. Bilirubin, a natural antioxidant derived from heme breakdown, has shown remarkable potential in scavenging ROS and mitigating their detrimental In recent years, the development of nanomedicines has emerged as a promising approach for targeted drug delivery and enhanced therapeutic efficacy. This review explores the utilization of bilirubin nanomedicines as a novel strategy for the treatment of ROS-mediated diseases. Various biocompatible nanoparticles, including liposomes, polymeric nanoparticles, and lipid nanoparticles, have been employed to encapsulate bilirubin, ensuring its stability and improving its pharmacokinetics. Additionally, surface modifications of nanoparticles with ligands enable targeted delivery of bilirubin to specific cells or tissues affected by oxidative stress. Conjugation of bilirubin to nanoparticles further enhances its stability, cellular uptake, and controlled release in response to ROS or other stimuli.