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INTRODUCTION: The birth of a child is a joyous occasion filled with great anticipation. The first minute after birth, on the other hand, is filled with anxious moments and rapid physiological adjustments. The majority of newborns make the transition successfully as a matter of course. However, 10% of them may need to be modified. When they are critically ill, they require advanced medical care. Mechanical ventilation is a common therapy in sub acute and long-term care settings and is routinely required for the critically ill in intensive care units. The primary goals of mechanical ventilation assistance are to restore normal arterial blood gas levels and acid-base balance by ensuring proper ventilation and oxygenation. AIM: To assess the knowledge regarding paediatric ventilator care among B.sc 3rdand 4th yearsNursingstudents.Materials And Methods: The research approach used for the study is non- experimental Comparative research design. The sample of the study is taken by non probability purposive sampling technique with 100 (50-50) B.sc 3rdand 4th yearsNursingstudents,svims, tirupati. The data collection done in the period of 20- 08-2022 A self structured questionnaire was used to collect the data consist of 30 multiple choice questions. The data analyzed statistically. Mainly chi-square was used for data analysis. Results:The major findings of the study was out of 50 selected B.sc 3rdand 4th yearsNursingstudents, svims, Tirupati,Out of 50Bsc nursing 3rd year 26(52%) had moderate knowledge on pediatric ventilator care , out of 50 Bsc nursing 4th year students 27(54%) had moderate knowledge on pediatric ventilator care. There is no statistical significant association with the knowledge regarding pediatric ventilator care. The comparison of knowledge scores regarding pediatric ventilator care among bsc nursing 3rd year and 4th year students among 3rd year bsc nursing students mean were 19.7 , standard deviation were 2.967 and standard error were 0.419. among the bsc nursing 4th year students mean were 21.28, standard deviation were 3.387, and standard error were 0.479 among all the bsc nursing 3rd and 4th year students the t value were 2.482.CONCLUSION:The study shows the knowledge regarding pediatric ventilator care among bsc nursing students were having moderate knowledge. Based on the providing information booklet was given to all the students to improve the level of knowledge.