Published Paper Details:

Sinusitis is a prevalent inflammatory condition affecting the paranasal sinuses, causing discomfort and reduced quality of life for millions of individuals worldwide. Nasal sprays have emerged as a promising delivery system for sinusitis treatment due to their localized action and improved drug bioavailability. In this study, we aimed to develop a microemulsion-based nasal spray formulation using Basil oil, Eucalyptus oil, and Rosemary oil as the active components for the treatment of sinusitis. The microemulsion formulation was prepared by combining the selected oils with a suitable surfactant, co-surfactant, and an aqueous phase. The selection of Basil oil, Eucalyptus oil, and Rosemary oil was based on their known therapeutic properties in alleviating sinusitis symptoms. Various ratios of the oils were screened to determine the optimal combination that provided the desired characteristics, such as stability, droplet size, and drug release properties. The prepared microemulsion-based nasal spray formulation was evaluated for its physicochemical properties, including pH, viscosity, droplet size, and drug content. In vitro drug release studies were conducted using a modified Franz diffusion cell to assess the release profile of the active components from the nasal spray formulation. The optimized formulation was further subjected to stability testing, including physical appearance, pH, viscosity, and drug content analysis, over a three-month period. The results indicated that the developed microemulsion-based nasal spray formulation using Basil oil, Eucalyptus oil, and Rosemary oil as the active components exhibited favorable physicochemical properties, such as a small droplet size, low viscosity, and uniform drug content. In vitro drug release studies demonstrated sustained release profiles, which are crucial for prolonged therapeutic effects. Stability testing revealed that the optimized formulation remained stable, with no significant changes observed in its physical appearance, pH, viscosity, or drug content during the storage period. In conclusion, the development of a microemulsion-based nasal spray formulation utilizing Basil oil, Eucalyptus oil, and Rosemary oil as the active components presents a promising approach for enhancing drug delivery and efficacy in sinusitis treatment. The optimized formulation displayed desirable physicochemical properties, sustained drug release, and long-term stability. Future in vivo studies are warranted to evaluate the therapeutic effectiveness and safety of this microemulsion-based nasal spray for clinical applications in sinusitis treatment.