Published Paper Details:

Mouth dissolving tablets are a type of solid dosage form that contains medication that dissolves quickly when pressed on the tongue, usually in a couple of seconds. Due to its simplicity in administration, it is becoming more and more popular among patients who have swallowing issues, particularly children, the elderly, and those who have dysphagia. Objective of this study was to investigate how natural polymers such as Soy polysaccharide, Lepidium sativum mucilage and fenugreek gum could be used as superdisintegrants in mouth dissolving tablets that dissolve in the mouth. Aim of the study was to develop the mouth dissolving combination tablets of Montelukast Sodium and Levocetirizine Dihydrochloride using natural polymers such as Soy polysaccharide, Lepidium sativum mucilage and fenugreek gum as superdisintegrants, optimization and evaluation by comparing them to the formulation containing typical synthetic superdisintegrants Croscarmellose sodium. Mouth dissolving combination tablet was prepared by direct compression method. Blended powder and compressed tablets were subjected to different physicochemical characterization and result revealed that blended powder and tablets had admissible properties. Formulations F3, F5 & F9 containing 8% of Soy polysachharide, 5% of Lepidium sativum mucilage and 9% of fenugreek gum respectively was given promising outcomes and results were comparable with formulation containing synthetic superdisintegrant CCS. Thus, it can be said that the produced mouth dissolving tablets dissolve instantly without the need for water and exhibit rapid dissolution rate.