Published Paper Details:

Background:Diabetes mellitus is a chronic disease that can result in both macrovascular and microvascular complications.Diabetic retinopathy is one of the most commonmicrovascular complication of diabetes mellitus. Epidemiologicallynumber of adults worldwide with DR, and vision-threatening DR was estimated to be 103.12 million, and 28.54 million respectively. The prevalence of diabetic retinopathy will betwice as much by 2045 as the current statistics. Since DR is a chronic disease and pharmacological treatment will help the patient's health by slowing down the disease progression.In this systematic review, we have focusedon the efficacy of combination national therapyof both pharmacological and herbal antioxidants in diabetic retinopathy.To study a correlation between diabetic retinopathy and natural antioxidants.The systematic review includes two databases PubMed and google scholar for reference data. The data extraction is based on PRISMA guidelines. Supplements irrespective of trace quantity also showedremarkable role. Curcumin, Vitamins, and Zinc are discussed in this systematic review.This systematic review concluded the results in which curcumin emerges to be the best antioxidant with specific characteristics and low adverse drug reactions.Others such as vitamins, Zinc also provide adequate antioxidant properties. Supplementation is often beneficial and necessary if dietary intake is below recommended guidelines. Overall, it was observed that herbal antioxidants are the choice of non-pharmacological treatment.