Published Paper Details:

ABSTRACT Colon-targeted drug delivery systems have gained significant attention as a promising approach to enhance the therapeutic efficacy of drugs for the treatment of various gastrointestinal disorders. These systems aim to deliver drugs specifically to the colon, thereby improving drug localization, reducing systemic side effects, and increasing patient compliance. Although the oral route is thought to be the most preferred method for administering drugs with a systemic effect, it is not recommended for administering drugs for lower gastrointestinal (GI) diseases because these medications release at the upper GI tract (stomach, small intestine), which further reduces their accessibility at the lower GI tract. The review begins by discussing the physiological considerations of the colon, including its anatomy, pH,enzymes, and transit time, which influence drug delivery to this region. Various approaches for colontargeting are then presented, including pH-dependent systems, time-dependent systems, microbially triggered systems, prodrug approach to drug delivery to colon. It also consists of novel approaches of colon targeted drug delivery such as pressure Controlled drug delivery system, Osmotic controlled drug delivery (OROS-CT),CODES technology, Port System, Pulsin Cap system ,Microspheres and Mucoadhesive approach. Moreover, the applications of colon-targeted drug delivery systems in the treatment of various diseases, such as inflammatory bowel disease, colorectal cancer, and irritable bowel syndrome, are explored.