Published Paper Details:

A few unique substituted azetidinones were synthesized and evaluated for their potential as prospective new therapeutic molecules for the treatment of depression. All of the produced compounds were evaluated for the clarity of their structures. These chemicals' antidepressant trials revealed that they exhibited strong antidepressant effect. Three stages of SN2 type substitution were used in the synthesis of the compounds. The stretching vibration peaks caused by C-N, C=O, and C=N were seen in the IR spectra of all the compounds at 1400-1000 cm-1, 1765-1645 cm-1, and 1690-1520 cm-1 (middle), respectively. The spectra also showed vibrations from the aromatic compounds C=C and C-H, C-H alkane, C-Cl (4e), CO (4d), C-H (methoxy), C-C (cycobutyl), and C=O. (cycobutyl). The test chemical 4d considerably enhanced the swimming frequency in FST. TST-like action was seen, and compounds 4a, 4b, 4c, and 4e did not perform as anticipated.