Published Paper Details:

Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Lansoprazole Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi-Carbonate: Citric acid as gas generating agent. The In-vitro dissolution profiles of all the prepared Lansoprazole floating drug delivery system formulations were found to extend the drug release over a period of 8 hours and the drug release rate decreased with increase in polymer concentration, it is concluded that formulation F5 (HPMCK4M: Eudragit-RL100) is the best formulation among all other formulations because it is showing very controlled release of drug from tablet formulation 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours. concluded that the drug release from F5 (HPMCK4M: Eudragit-RL100) shows that, as HPMCK4M used in combination with Eudragit-RL100, the drug release of formulation is increases as compare to F1-F4 (HPMCK4M) & F6-F8(Eudragit-RL100: HPMCK4M). All the developed floating tablets floated up to 12 hour