Published Paper Details:

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative condition related with ageing and marked by cognitive decline. The cognitive functions include altered behavior, a diminished ability to learn, and memory loss that results in dementia. The hippocampus, cerebral cortex, and other parts of the brain develop beta-amyloid (A) fibrils, oligomers, and neurofibrillary tangles (NFTs), which are the root cause of AD. Studies that are now available indicate that gene mutation, protein aggregation, excitotoxicity, protein aggregates, oxidative stress, and mitochondrial dysfunction are the main mechanisms contributing to the pathogenesis of AD. A collection of microorganisms needed to support the digestive system makes up the gut microbiota. The microbiota-gut-brain axis is a dynamic, bidirectional communication system that connects the functions of the peripheral intestine with cognitive and emotional awareness. This chapter encompasses around the role of gut microflora in Alzheimer's Disease and also the role of probiotics, prebiotics and synbiotics in AD.