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Hamelia patens (Rubiaceae) is a widely cultivated decorative plant that thrives in warm and humid regions across the globe.A significant portion of the global population continues to rely solely on plants for medicinal purposes, with plants being the primary source of active ingredients for the majority of traditional medicinal products. Hamelia patens Jacq. (Also known as H. erecta Jacq.) is a sizable evergreen shrub that is native to the Americas. It was brought to India as a decorative plant and cultivated in gardens. This perennial bush thrives both in sunny areas and in shaded environments. The utilization of this plant in traditional medicine extends to a variety of health conditions. It exhibits analgesic, antiseptic, anti-inflammatory, febrifuge, and refrigerant properties. Hamelia patens contain oxindole alkaloids, Flavonoids. Other chemical constituents are ephedrine, carbohydrate, proteins, tannins.This review explain about chemistry &Pharmacological investigations of Hamelia patens that have validated by different researchers.