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Background Smoking is an escalating public health problem especially in a developing country like India. Active smoking has been associated with endothelial dysfunction an high lipid profile including lower levels of high-density lipoprotein (HDL). Thus lipid profile is a simple investigation which helps estimate future cardiovascular morbidity and mortality among smokers Method Laboratory investigations are done in 50 subjects and their Total Cholesterol, Triglyceride, and HDL-C are estimated. LDL-C and VLDL are calculated by using friedewald formula This is a retrospective study done in biochemistry department of Lourdes Hospital Ernakulam, Kerala during three month period. Result In the present study, the results showed that the serum level of total cholesterol, triglyceride, LDL-C, and VLDL-C were significantly higher in smokers as compared to non-smokers. Conclusion India is one of the largest consumers of tobacco in the world. Addition of tobacco smoking is related with many health hazards. Nicotine of tobacco can be attributed to changes in lipid profile and atherogenic complications due to increasing the atherogenic lipoprotein(LDL-c) with a further decrease in antiatherogenic lipoprotein(HDL), such changes are associated to occurrence of cardiovascular disease with high risk of morbidity even mortality. So smokers should be counseled about health hazards of smoking and encouraged to quit smoking and adapt healthy lifestyle to improve the life.