Published Paper Details:

conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are less soluble at alkaline pH of intestine. Further drugs which produce their local action in the stomach get rapidly emptied and do not get enough residence time in stomach. Hence, the frequency of dose administration in such cases is increased. To avoid these problems, various efforts have been made to prolong the retention time of drug the stomach. Floating drug delivery system (FDDS) is one of the most important approaches in prolonging the retention time of the drug in the stomach, FDDS is low density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric contents, the drug is released slowly at the desired rate which results in better control of the fluctuations in plasma drug concentration. Based on the mechanism of buoyancy, Sodium alginate, carnauba wax and bees wax were selected for the preparation of floating alginate wax beads. The identity of Cilnidipine was confirmed by physical characteristics, spectrophotometric analysis such as Ultra violet visible spectrophotometric, Fourier Transform - Infra red and differential thermal calorimetric studies by preparing the floating alginate wax beads of Cilnidipine, the effect of different variables on floating alginate wax beads was studied. The prepared floating beads were evaluated for micromeritic properties, % drug contents, floating lag time, floating time, swelling index and % drug release in 0.1N Hydrochloric acid and its accelerated stability study