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The present study is aimed to assess, histological changes in the gills of the freshwater fish Channa punctatus (Bloch), caused by zinc toxicity. Fish Channa punctatus were exposed to three sub-lethal concentrations of zinc for 15 days. The effects of this exposure have been studied on histology of gills at intervals of 8, 10 and 15 days. Severe histopathological changes were observed in gills of all exposed groups. Severity of damage in the gills were time and does dependent. Result suggests that zinc treatment probably dysfunction the detoxification mechanism of the organ. Present investigation indicate that histological damage caused to the gill tissue may result in hypoxia (respiratory distress) followed by other deleterious changes culminating in death of animal.The present study is aimed to assess, histological changes in the gills of the freshwater fish Channa punctatus (Bloch), caused by zinc toxicity. Fish Channa punctatus were exposed to three sub-lethal concentrations of zinc for 15 days. The effects of this exposure have been studied on histology of gills at intervals of 8, 10 and 15 days. Severe histopathological changes were observed in gills of all exposed groups. Severity of damage in the gills were time and does dependent. Result suggests that zinc treatment probably dysfunction the detoxification mechanism of the organ. Present investigation indicate that histological damage caused to the gill tissue may result in hypoxia (respiratory distress) followed by other deleterious changes culminating in death of animal.