Published Paper Details:

Abstract: Urinary tract infection (UTI) is a bacterial infection that affects any part of the urinary tract. When bacteria get into the bladder or kidney and multiply in the urine, they cause a UTI. The most common type of UTI is a bladder infection which is also called cystitis. Another kind of UTI is a kidney infection, known as pyelonephritis, and is much more serious. The diagnosis of UTI is confirmed by a urine culture. Uropathogenic Escheria coli (UPEC) is responsible for approximately 90% of UTI seen in individuals with ordinary anatomy. Uropathogenic Escheria coli utilize Pfimbriae (pyelonephritis -associated pili)to bind urinary tract endothelial cells and colonize the bladder. These adhesins specifically bind D-galactose-D- galactose moieties on the P blood group antigen of erythrocytes and uroepithelial cells. Approximately 1% of the human population lacks this receptor,and its presence or absence dictates an individual's susceptibility to Escheria coli urinary tract infections. UPEC can evade the body's innate immune defence, the complement system by invading superficial cells to form intracellular bacterial communities(IBCs).IBCs have the ability to form K antigen, capsular polysaccharides that contributes to biofilm formation. Biofilm producing Escheria coli are recalcitrant to immune factors and antibiotic therapy and are often responsible for chronic urinary tract infections. Quinolones are a family of broad spectrum antibiotics. They inhibits the bacterial DNA gyrase or topoisomerase IV enzyme thereby inhibiting DNA replication and transcription. The present study reveals the prevalence rate of quinolone resistant isolates of Escheria coli from patients suffering from UTI attending in SRM Medical college hospital and Research Centre, Chennai.