Published Paper Details:

The complex stratum corneum barrier is the main obstacle to the transdermal administration of medicines. Modern lipid-based nanosystems, in particular transethosomes, have the capacity to penetrate the stratum corneum's dense network. They have demonstrated to be an effective technique for the transportation of medicines. Transethosomes(TELs) are composed of phospholipid, ethanol, water and edge activator(surfactants) or permeation enhancer(oleic acid). Delivering medication molecules into the circulation is made possible by the softness and flexibility that ethanol and edge activator both offer. Various techniques involved in the formulation of transethosomes are Cold method, Hot method, Thin film hydration method and Mechanical dispersion method. Compared to other vesicular systems, transethosomes have small particle sizes and are easily able to change the shape of vesicles, allowing them to pass through the layers of skin. The characterization of vesicles include Size of the particle and surface charge, Trasmission Electron microscopy, determination of entrapment efficiency, surface morphology study, interaction study by DSC and FTIR, drug content and stability of vesicles. These vesicular system can be used for transdermal delivery of various drugs such as NSAIDS, antifungal, antibiotics, antiparkinsonism, antiviral etc., In this review, the applications, challenging problems, and potential future developments of transethosomes were examined along with their nature, methods of preparation, and evaluation parameters.