Published Paper Details:

Oral route of drug administration is most favorable for most of the patients. It is easiest, convenient, patient compliance, non-invasiveness method and is preferred by most of the physicians. The oral administration of biologics yet not beneficial compared to other routes due the various gastrointestinal barriers, mucosal permeability also it limits the systemic absorption of macromolecules that are complex after ingestion. Biologics contribute in significant treatment of therapeutic interventions such as chronic ailments, metabolic disease ageing and inflammatory disorders but are highly sensitive to the harsh environment of the gastrointestinal tract; the large molecular size causes the permeability across the intestinal mucosa to become extremely poor for biologics. Various drug discovery, intensive research and design have enhanced the growth of biologics in recent decades' and have further accelerated in the way we administer the medication in a clinical settings. . Different drug delivery systems pharmaceutical technologies that include micelles, nano carriers, lipid-based carriers, and cyclodextrins have been explored to enhance oral drug absorption. This article will first address the physiological barriers to oral delivery of biologics and discusses different strategies to improve the effectiveness of oral delivery. Additionally, this discussion will extends to the various advantages and limitations of drug delivery systems as well as the overall opinion and potential of this future clinical field.