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Background of the study- Rag-pickers are always living in high risk areas; it is a source of various types of physical and psychological illnesses. Rag picking is one of the most neglected sectors in society, and they have lack of adequate information and magnitude of problems and substance abuse practices, hence the rag pickers are more prone for psychological problems. Rag pickers suffer from many problems such as skin problems, musculoskeletal problems and occupational health problems i.e. cuts, prick injuries, animal bite etc. Aim of the study- To assess the physical health problems and psychological well-being among rag pickers Methodology- A descriptive design was used to assess the physical health problems and psychological well-being among rag pickers in selected areas of district Ludhiana, Punjab. The sample of study was 200 rag pickers. Structured checklist and rating scale was used for data collection. Data was collected by interview schedule and analysed by using descriptive and inferential statistics. Results- Findings of the present study revealed that all rag pickers had at least one or more health problems. Majority 185 (92.5%) of rag pickers suffered with integumentary problems. Maximum 172 (86%) rag pickers had foul breath followed by 86 (43%) were having discolouration of teeth, 173 (86.5%) subjects reported lice in hair, 24 (12%) subjects had skin itching. Half of subjects 100 (50%) had cuts and 96 (48%) subject had prick injuries. 96 (48%) rag pickers had low psychological well-being followed by 75 (37.5%) rag pickers had moderate psychological well-being and 29 (14.5%) rag pickers had high psychological well-being. Conclusion- Present study concluded that all rag pickers had one or more physical health problems. Majority (92.5%) of rag pickers suffered with integumentary problems and (48%) rag pickers had low psychological well-being. It was found that there was significant association of musculoskeletal problems with psychological well-being and gastrointestinal problems with period of stay in slums.