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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
Crystal Engineering of Lansoprazole for Solubility and Bioavailability Enhancement.
Authors
Snehal N. Pawar, Vivek M. Thorat, Shyam S. Rathod, Milind D. Kamble, Ganesh G. Tapadiya
Keywords
Lansoprazole, Co-crystal, Solubility, Dissolution
Abstract
The existing work deals with the purposes of synthesis and characterization of lansoprazole co-crystals with various conformers. Nine conformers were selected under the study to prepare co-crystals of lansoprazole for enhancing its solubility, dissolution, and bioavailability. The formulated co-crystals were characterized by FTIR, DSC, PXRD, saturation solubility study, in vitro dissolution studies, and stability study. The conclusion of the study shows a major improvement in solubility with piperazine co-former. Lansoprazole and piperazine co-crystal 1:1M were formulated as tablets. The results show that solubility and dissolution of lansoprazole were enhanced by co-crystallization and it shows pharmaceutical stability
IJCRT's Publication Details
Unique Identification Number - IJCRT2303556
Paper ID - 233024
Page Number(s) - e898-e904
Pubished in - Volume 11 | Issue 3 | March 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Snehal N. Pawar, Vivek M. Thorat, Shyam S. Rathod, Milind D. Kamble, Ganesh G. Tapadiya, "Crystal Engineering of Lansoprazole for Solubility and Bioavailability Enhancement.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 3, pp.e898-e904, March 2023, Available at :http://www.ijcrt.org/papers/IJCRT2303556.pdf
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Volume 12 | Issue 7
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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