Published Paper Details:

In Cancer Therapy there are many problems like multi drugs therapy, short circulation half-life and nonspecific systemic distribution. Important Process to deal with these concerns is to style a drug delivery vehicle that has versatile functionality, good serum stability, circulates within the body long enough to succeed in the targeting tissues and is biocompatible. These features are overcome by formulating the lipid-polymer hybrid nanoparticles. The surface characteristics of these nanoparticles such as charge, lipid density and targeting ligand can be modified to allow for specific cellular uptake, controlled vincristine sulfate and a lomustine releases kinetics, and enhanced pharmacokinetics. Present study show that the hybrid nanoparticles could easily be formulated with negatively and positively charged lipids in order to change the overall surface charge. The particle size remained in the distribution was narrow and desirable range. The present Formulation has the capacity to co-encapsulate vincristine sulfate and a lomustine. To investigate, vincristine sulfate and a lomustine were dually loaded within the hybrid nanoparticle system. This combination formulation was characterized by dynamic light scattering for zeta potential, particle size and poly-dispersity index, in-vitro vincristine sulfate and a lomustine release and cytotoxicity. The release studies showed that addition of the vincristine sulfate and a lomustine within the lipid-polymer hybrid nanoparticle system didn't affect the vincristine sulfate and a lomustine release profiles of the each vincristine sulfate and a lomustine.