Published Paper Details:

Rapid, precise, and accurate RP-HPLC method developed for simultaneous estimation of Vosaroxin hydrochloride and Cytarabine hydrochloride in synthetic mixture. Combination of Vosaroxin hydrochloride and cytarabine hydrochloride was studied under clinical trial phase III. It was proved that the combination is effective in Cancer patient. The combination of Vosaroxin with cytarabine produced synergistic cytotoxic effects in human leukemia cell lines and primary AML blasts. Safe and effective treatments are urgently needed for patients with relapsed or refractory acute myeloid leukemia. The efficacy and safety of Vosaroxin, a first-in-class anticancer quinolone derivative, plus cytarabine in patients with relapsed or refractory acute myeloid leukaemia. From the literature survey, it was found that even though individually both drugs have been analysed by few methods, but no analytical method has been developed and validated for analysis of Vosaroxin hydrochloride and Cytarabine hydrochloride in combination and no Single Patent has been found on Analytical Method Development and Validation for Simultaneous Estimation of Vosaroxin hydrochloride and Cytarabine hydrochloride in Synthetic Mixture. Therefore, it was thought of interest to develop and validate Stability Indicating RP- HPLC method for Simultaneous estimation of Vosaroxin hydrochloride and Cytarabine hydrochloride in synthetic mixture.