Published Paper Details:

Opioids are frequently used as analgesics by HIV patients. Contrary to popular belief, new clinical data show that using opioid analgesics frequently really worsens the state of chronic pain. The World Health Organization's most recent study estimates that there are roughly 37.9 million HIV/AIDS patients worldwide. Around 30- 40% of them experience HIV-related discomfort. A significant percentage of chronic pain is neuropathic pain, which is described as chronic pain brought on by diseases or lesions of the nerve system and manifesting as a variety of symptoms of the neurological system, including both positive and negative signals. HIV-related neuropathic pain is believed to be generated by a maladaptive process that initially served to promote regeneration and healing injury induced by HIV protein, central and peripheral sensitization, and side effects of antiretroviral medication. It has been discovered that Gp120, an HIV envelope protein, is the main toxin that causes neuropathic pain. In particular, during HIV infection, the microglia, which release a variety of pro-inflammatory molecules (including TNF, IL-1, and IL-6), not only cause the neurons to become more sensitive, but they also play a key role in the cross-talk connecting the astrocytes and oligodendrocytes to create the central sensitization.This review mainly focus on the mechanism of hiv related neuropathic pain and association with opioids