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Anybody at any time can experience agantujavyadhis and if not treated properly can lead to devastating permanent health problems. The branch Agad tantra deals with such category of diseases. This branch had flourished in old days, since poisoning was the major warfare technique. The clinical skills of professionals trained in Agad tantra is for accurate diagnosis and treatment had astonished even the invaders of the country itself. But now the treatment modalities exclusive for Agad tantra is on the verge of extinction. Lack of scientific evidences, trained professionals and institutional supports are the main reasons. Due to geographical peculiarities, Kerala had made remarkable contribution to Visha chikitsa. Kerala has developed its own snake bite management protocols by widely practicing visha vaidyas at that time and recorded in Keraliya visha chikitsa granthas. They had introduced special treatment modalities like Uttu chikitsa, Talam, Tukkudhara etc. This review details such a special treatment modality called Uttu chikitsa mentioned in Vishavaidya Jyotsnika and Prayoga Samuchaya.