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ABSTRACT BACKGROUND: Low back pain (LBP) is one of the most common musculoskeletal issues experienced by the adults in their life time. People with age 35-55 are more prone to Low Back Pain. This persistent pain condition may include the central sensitization (CS) phenomenon, which implies a wide range of symptoms and that may be taken into account in LBP treatment. CS symptoms can be measured by the Central Sensitization Inventory (CSI). OBJECTIVE: The aim of the study was to explore association of CS with disability. METHODOLOGY: In present cross-sectional study total of 100 Gujarati participants aged 33-55, suffering from LBP were included. CS symptoms were measured with the Gujarati Version of the CSI and disability was measured by ODI Gujarati version Statistical analysis was done by using SPSS 20 version. Spearman�s rank correlation coefficient test, Mann Whitney U test was applied for co-relation and between group comparisons respectively. Significance level was set at p<0.05. RESULT: The mean CSI total score for the whole sample was 35.49�5.26 points. CSI total score had subclinical values in the whole sample; The CSI mean total score was 34.49�5.26 points for females and 35.16�5.22 points for males. Patients showed significant differences in CSI total score by gender (P = 0.000). There were statistically significant moderate positive correlation between CSI score and ODI score CONCLUSION: Present study concludes that there moderate positive correlation between CSI score with disability. Although participants showed mean subclinical values in CSI total score, participants with scores ?40 were found across chronic low back. In particular, females with LBP participants were most affected by high CSI scores. In light of these results, it is recommended that clinicians supplement their assessment with the CSI in low back patients for improved decision-making during treatment.