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Dostarlimab (JEMPERLI), a PD-1 monoclonal antibody, is used to treat adult patients with advanced or recurrent endometrial cancer who have progressed while receiving treatment with a platinum-containing regimen or after receiving prior therapy. This application was swiftly approved based on the rate of tumour response and the length of the response, both of which were determined using an FDA-approved test. The continuation of approval for this indication is dependent on additional confirmatory trials proving and proving therapeutic benefit. The clinical trial NCT04165772 showed a rectal cancer remission rate of 100% in June 2022. This clinical trial demonstrated that it is possible to match a tumor's genetics with its treatment. Patients are still being enrolled in this research trial, A few decades ago, the incidence of colorectal cancer was low. Nonetheless, it has emerged as a common malignancy and now represents 10% of cancer-related deaths in western nations. The "surge" in colorectal cancer cases in developed nations is thought to be caused by an ageing population, poor modern eating practises, and an increase in risk factors like smoking, inactivity, and obesity. Laparoscopic surgery for primary disease, more aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies are some of the new treatments for primary and metastatic colorectal cancer that have emerged, giving patients more options. On cure rates and long-term survival, these new therapy alternatives haven't made much of a difference.