Published Paper Details:

An efficient method for the synthesis of symmetrical and unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such as amines and carbon disulfide In aqueous medium is presented. The present method is also useful in substituted 2-mercapto imidazole heterocycles .The products were purified Through precipitation, which involves changing the pH value, followed by Recrystallization. The products were identified by melting point and infrared spectroscopy. The geometry of the proposed structures of the chelates based on their electronic spectra, electron spin resonance (ESR) and magnetic Susceptibility. The stability of complexes was studied by TGA analysis (Thermal studies). The practical two-step synthesis of 1-phenylthiourea is reported here as an undergraduate experiment for the organic synthesis laboratory. The products were purified through precipitation, which involves changing the pH value, followed by recrystallization. The products were identified by melting point and infrared and NMR spectroscopy. [1] Phenylthiourea and its derivatives have attracted interest due to their excellent combination of properties such as high corrosion resistance, anti-viral activity, strong hydrogen bonding and inhibition of bacterial adhesion to the submergible surface within the aqueous system [2,3] In present work we have synthesized substituted phenylthiourea. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. All the synthesized compounds were screened for their antimicrobial activities. These compounds were found to have antimicrobial activities comparable to and in some cases greater than those of equimolar quantities of standard drug. [4].