Published Paper Details:

Background: COVID-19 is an infectious disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) created a devastating impact on global health and economy. This study aids in understanding the clinical and immunological response of children during third wave of COVID. Methods: A Cross sectional study conducted among school going children of age 4-17 during Jan 22 to April 22.Demographic and clinical parameters were assessed based on structured questionnaire. Serum samples were collected from volunteered children who were not vaccinated against COVID-19. COVID-19 Ig G antibodies were estimated using CLIA and the data analyzed using SPSS. Results: 87 children were enrolled from a school.32.2% were girls; 67.8% were boys.78% of the children had fever, 86% had cold, 64% had cough and 64% had headache. Majority were having symptoms for 3-5 days. Serum samples were collected for COVID-19 IgG levels from 23 COVID-19 unvaccinated children, out of which 19(82.6%) were positive for COVID. The mean COVID-19 IgG level around 2 months after recovery was 24.6 IU. Conclusion: This study suggests that children who had fever, cold and cough during third wave had COVID-19 disease and had an overall better prognosis. Future longitudinal studies are necessary to confirm our findings and to better understand the protective IgG levels which prevent further infections in COVID-19 vaccinated and unvaccinated children.