Published Paper Details:

ABSTRACT In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Floating drug delivery system is one of the several techniques currently used to formulate a successful gastro retentive drug delivery system. Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents the drug is released slowly at the desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration. In the present research we have studied pea nut husk powder as a floating agent. Floating tablets were prepared by direct compression method using Atenolol and in various concentrations of the polymers HPMC K100M and Peanut Husk powder. Among three formulations F1 has shown a drug release of 94.2% after 12hrs and F1 has shown a floating lag time of 1.07mins.Based on in vitro dissolution studies and floating studies, increased concentration of peanut husk powder improves the floating nature but drug release is retarded due to increase in concentration of HPMC K100M. The optimized formulation followed Higuchi kinetics. It can be concluded that peanut husk powder can be a promising low density material in the formulation of gastro retentive floating drug delivery systems in combination with synthetic polymer HPMC K100M.