Published Paper Details:

Pyridazines are the important heterocyclic compounds containing nitrogen atom in their cyclic rings . These pyridazines belongs to the heterocyclic class of diazines. The pyridazine is an important structure for various biological activities[1].This fused heterocyclic systems represents a commonstructural features for many bioactive compounds showing a variety of pharmacological activities. These activities of pyridazine is important for the design and development of new drugs. Pyridazine shows a wide range of pharmacological activities such as antihypertensive, anti-depressant, hepatoprotective, antiviral, anti-cancer, antimicrobial, cardiotonic, vasodilation, analgesic, anti-inflammatory etc[2].Synthetic pyridazine compounds acts as effective antiprostaglandins (PGs), S-lipoxygenase (S-LOX) and antiplatelet agents, that is, inhibitors of prostaglandin or cycloxygenase ( COX-I & COX-II) enzyme, plateletcAMP , phosphodiesterase and thrombaxane A2 ( TXA2) synthase. These pyridazines also acts as selective and non-selectiveCOX inhibitors. This review summerizes about the most relevant pharmacological properties of pyridazine derivatives.