Published Paper Details:

Copper, Nickel, Manganese, Cobalt and Iron complexes of Mixed ligands (L: Diketimines & 1,10-Phenanthraline) have been prepared and characterized by IR, UV-Vis and Cyclic voltammetry. Planar compound have numerous application in biological system such as antioxidant, antiviral and antimutagenic activities. Current research works have been published on Diketimines moiety with metal to explain the factors that are key in their biological character. It is also expected that the ability of Diimines and planar compound to chelate with metals is very important factor for their biological activities. Therefore, we here tried to explore the interaction of these mixed metal complexes with herring sperm DNA using spectral and electrochemical methods. Complexes 1-3 exhibits hypochromism with red shift and octahedral complexes shows hyperchromism with blue shift. All these metal complexes observed binding constants fall in the range of 0.85 x 105 M-1- 2.1 x 103 M-1 and electronic spectra conclude that, complexes 1-3 and 4-5 bind with DNA through intercalation and groove binding respectively. Electrochemical studies expose that the metal complexes (1-3) prefer to bind with DNA in M(II) form. The stong positive potential shift in complexes, 1-3 may be attributed to the intercalation binding and the slight positive potential shift in the complexes, 4 & 5 may be due to groove binding. CD spectral studies also suggest that the complexes, 1-3 and 4-5 bind with DNA through intercalation and groove binding respectively.