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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
VARIOUS APPROACHES TO IMPROVING THE AQUEOUS SOLUBILITY OF POORLY WATER-SOLUBLE DRUGS USING SOLID DISPERSION
Authors
Mr. Rohit S. Bhamare, Prof. R. K. Surawase, Prof. Jayshree Bhadane, Mr. Pushkar S. Chavan, Mr. Sandesh Y. Pawar
Keywords
Solid dispersion, Solubility enhancement, Solvent evaporation, Fusion method.
Abstract
Oral route administration is the most desirable and preferred method of delivering therapeutic agents due its systemic effects. Presently days, various hydrophobic drugs were coming into the market. Disadvantage of these drugs are its bioavailability issues because of poor gastric fluid dissolubility. In this way, it is important to improve its solubility and its penetrability in this manner improving the disintegration, absorption and bioavailability of these drugs. About 40% of orally administered drugs have formulation difficulties due to their insolubility in water. The dissolution rate, absorption, distribution and excretion of drugs depends on its solubility properties. Based on solubility, drugs are classified into the four classes of BCS classification. BCS class II and class IV drugs shows poor water solubility.
IJCRT's Publication Details
Unique Identification Number - IJCRT2302257
Paper ID - 231076
Page Number(s) - c78-c87
Pubished in - Volume 11 | Issue 2 | February 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Mr. Rohit S. Bhamare, Prof. R. K. Surawase, Prof. Jayshree Bhadane, Mr. Pushkar S. Chavan, Mr. Sandesh Y. Pawar, "VARIOUS APPROACHES TO IMPROVING THE AQUEOUS SOLUBILITY OF POORLY WATER-SOLUBLE DRUGS USING SOLID DISPERSION", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 2, pp.c78-c87, February 2023, Available at :http://www.ijcrt.org/papers/IJCRT2302257.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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