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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
INVESTIGATION ON HEPATOPROTECTIVE ACTIVITY OF ZIZYPHUS XYLOPYRUS (RETZ.) WILLD STEM BARK EXTRACTS AGAINST CARBONTETRACHLORIDE INDUCES LIVER DAMAGE
Authors
Neha Dwivedi
Keywords
INVESTIGATION ON HEPATOPROTECTIVE ACTIVITY OF ZIZYPHUS XYLOPYRUS (RETZ.) WILLD STEM BARK EXTRACTS AGAINST CARBONTETRACHLORIDE INDUCES LIVER DAMAGE
Abstract
In the present study, the hepatoprotective effects of petroleum ether and methanol extract of zizyphus xylopyrus stem bark extract were studied using the model of hepatotoxicity induced by carbon tetrachloride (CCl(4)) in rats. CCl(4) administration induced a significant decrease in serum total protein, albumin, urea and a significant increase (P <or= 0.01) in total bilirubin associated with a marked elevation in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) as compared to control rats. Further, CCl(4) intoxication caused significant increase in the TBARS and decrease in glutathione (GSH) levels in serum, liver and kidney. Both the extracts resulted in significant decreases in the activities of AST, ALT and ALP, compared to CCl(4)-treated rats. The results indicate that zizyphus xylopyrus stem bark extract possesses potent hepatoprotective effects against CCl(4)-induced hepatic damage in rats.
IJCRT's Publication Details
Unique Identification Number - IJCRT2302080
Paper ID - 230728
Page Number(s) - a666-a681
Pubished in - Volume 11 | Issue 2 | February 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Neha Dwivedi, "INVESTIGATION ON HEPATOPROTECTIVE ACTIVITY OF ZIZYPHUS XYLOPYRUS (RETZ.) WILLD STEM BARK EXTRACTS AGAINST CARBONTETRACHLORIDE INDUCES LIVER DAMAGE", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 2, pp.a666-a681, February 2023, Available at :http://www.ijcrt.org/papers/IJCRT2302080.pdf
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Volume 12 | Issue 7
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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