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Alternative medicine and natural remedies have been used since ancient times for the treatment and well-being of humans. Medicinal plants are considered to be effective and most important for the above purposes. Mother Nature has provided us with a huge count of flora and fauna. Some of the natural medicinal plants are so common that we use them in daily life without knowing their medicinal importance. Annona squamous L. is the best example of it. The fruit of this plant is commonly known as the custard apple which is eatable A. squamosa. and human beings were also providing updated facts of phytochemical and pharmacological approaches of the above plant in the present 21st century. A. squamosa L. is a multipurpose shrub tree that is distributed throughout tropical countries and eminently a desert fruit in India. The plant belongs to the family Annonaceae which in Hindi is known as Sitaphal or Sharifa which is utilized for its medicinal properties. The ethnobotanical traditional uses include wound healing, lice repellant, and treatment of dysentery and urinary tract infections. Phytochemicals include alkaloids (benzoxyquinazoline, salsolinol, coclaurine), terpenoids (annomosin A, annosquamosa in A), glycoside (quercetin-3-glucoside), essential oil (bicyclogernacrene, T-cadinol), flavonoids (kaempherol, farmarixetin) tannins, and much more responsible for pharmacological action of plant parts are fruits, seeds, leaves, bark, and flower. Information on medicinal uses and organoleptic properties of various pharmacologically active parts is also provided. The leaves are used as a vermicide, for treating cancerous tumors and are applied to abscesses, insect bites, and other skin complaints. Scrapings of root bark are used for toothache. Powdered seeds are used to kill head lice and fleas but care should be taken that the powder does not come in contact with the eyes as this causes great pain. The present article discusses the updated information regarding distribution, plant parts used, chemical constituents, and morphological and pharmacological importance of this plant hoping for exploring better medicinal value