Published Paper Details:

Abstract: Osteoarthritis (OA) is a degenerative disease that occurs due to the breakdown of joint cartilage in weight-bearing joints. In various in vivo and in vitro studies metformin showed benefits of delaying aging and prolonging life and has great potential for the treatment of other disorders. Because the way metformin works activates AMP-Activated Protein Kinase (AMPK) which has been assumed to be a potential target therapy for Osteoarthritis, it is possible that Metformin can be a therapy for Osteoarthritis. There have been several studies on experimental animal models of autoimmune arthritis that show that metformin also has anti-arthritic activity and inhibits bone degradation. To analyze the effect of metformin use in experimental rat animals that have been induced medial meniscus destabilization. Literature searches were obtained from PubMed and Google Scholar databases. The population of this study was experimental rats that had been induced medial meniscus destabilization. After reviewing relevant articles, 5 articles were determined to be eligible and were high quality articles. Researchers analyzed the effect of metformin administration on rat animals that have been induced medial meniscus destabilization. Metformin significantly affects the progression of Osteoarthritis in mice. Further studies in humans using the same evaluation parameters need to be conducted to prove the effect of metformin administration on Osteoarthritis progressivity in humans.