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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
IN-VITRO MUTAGENIC EVALUATION OF THE SULFASALAZINE IMPURITY (2-HYDROXY-5-[N-(4-{[4 -PYRIDINE- 2 -YLSULFAMOYL) PHENYL] SULFAMOYL}PHENYL)DIAZEN-1-YL]) BENZOIC ACID BY BACTERIAL REVERSE MUTATION TEST
Authors
Surya n Suryadevara
Keywords
: Bacterial Reverse Mutation Assay, Reverent Colonies, Mutation, Toxicology, sulfasalazine, and (2-hydroxy-5-[N-(4-{[4-pyridine-2-ylsulfamoyl) phenyl]sulfamoyl}phenyl)diazen-1-yl]) benzoic acid.
Abstract
Sulfasalazine is anti-inflammatory drug that was used in Rheumatoid arthritis and Ulcerative colitis. Pharmaceutical impurities are existing along with drug substances. Hence it is mandatory requirement to do safety studies of each impurity. The present study was performed to evaluate the mutagenic potential of Sulfasalazine Impurity (2-hydroxy-5-[N-(4-{[4-pyridine-2-ylsulfamoyl) phenyl]sulfamoyl}phenyl)diazen-1-yl]) benzoic acid in the Bacterial Reverse Mutation Assay using five tester strains. In this experiment there was no significance results were reported to establish the impurity as Mutagenic nature.
IJCRT's Publication Details
Unique Identification Number - IJCRT2212250
Paper ID - 228861
Page Number(s) - c368-c377
Pubished in - Volume 10 | Issue 12 | December 2022
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Surya n Suryadevara, "IN-VITRO MUTAGENIC EVALUATION OF THE SULFASALAZINE IMPURITY (2-HYDROXY-5-[N-(4-{[4 -PYRIDINE- 2 -YLSULFAMOYL) PHENYL] SULFAMOYL}PHENYL)DIAZEN-1-YL]) BENZOIC ACID BY BACTERIAL REVERSE MUTATION TEST", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 12, pp.c368-c377, December 2022, Available at :http://www.ijcrt.org/papers/IJCRT2212250.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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