Published Paper Details:

Commiphora mukul Hook. ex Stocks is a well-known medicinal plant and its gum is commonly known as Muqil or Guggul, which is an important herbal drug, widely used in the treatment of many clinical conditions, such as rheumatoid arthritis, hyperlipidemia, and obesity. Out of 165 species, 5 species of the plant are found in India. Muqil has been used either single or in combination with other drugs in Unani as well as Ayurvedic system of medicine for centuries. It is an oleo-gum resin obtained by making deep incision at the basal part of stem bark of Commiphora mukul belonging to the family Burseraceae. Muqil contains special group of steroidal compounds called guggulsterone, which are responsible for its therapeutic activity. E and Z guggulsterone are major constituents, which account for its use in arthritis. Other bio-active alkaloids present in Muqil include Naringenin, Cembranoids, Myrrhanol-A, Ellagic-acid, L-arabinose, Myrrhanol B, Muscanone, Diayamgambin, Quercitin,1-8 cineole, Mansumbinoic acid and Mansumbinone. Various preclinical and clinical studies have been conducted to evaluate its pharmacological activities. In this review paper, an attempt has been made to explore anti-inflammatory and anti-oxidant activity of Muqil, a herbal drug, used in the management of Rheumatoid-Arthritis.