Published Paper Details:

Sulfonylureas are a group of medicines used in the management of type 2 diabetes. Sulfonylureas lower blood glucose levels by stimulating insulin release from the beta cells of pancreas, which do not work in people with type 1 diabetes. Where 2nd generation sulfonylureas [ glimepiride] are among most used anti-diabetic medication as they are highly efficient and inexpensive. The effective dosage range is 1to 8mg/day which should be used with caution in elderly & in patients with renal/ hepatic disease. Where glimepiride, was generally associated with lower risk of hypoglycemia & less weight gain compared to other sulfonylureas. A 65 yrs. old female patient was admitted in general medicine ward, in a tertiary care hospital with chief complaints of hypoglycemia & was brought to emergency department for further management. While her past medical H/O indicates that she was taking oral hypoglycemic drugs [glimepiride-2mg] for 2yrs. Where, on laboratory investigation her GRBS-31mg/dl, and was managed by giving IV dextrose[25%] later on further examination her GRBS got improved & were monitored every 2nd hour & was advised to hold the diabetic medication. This adverse reaction is considered as drug related type ADR as per WHO scale. Glimepiride as it is causing severe hypoglycemia, alternative therapy concept i.e. by combination either with metformin/ insulin with lifestyle modifications is much efficient which can minimize the risk of hypoglycemia in geriatric patients with type 2 diabetes.