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  Published Paper Details:

  Paper Title

DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR DETERMINATION OF FEBUXOSTAT IN BULK AND PHARMACEUTICAL DOSAGE FORM.

  Authors

  Miss. Pragati Raju Kamble,  Miss. Nikita Vilas Pandagale,  Mr. Omkar D. Ghatage,  Mr. Pramod B. Patil,  Dr. S. V. Patil

  Keywords

Febuxostat, HPLC, RP-HPLC, Regression, Spectroscopically.

  Abstract


A new accurate, specific, precise, high performance liquid chromatographic (HPLC) method has been developed and validated for the determination of Febuxostat in bulk and in its pharmaceutical dosage forms of tablet. Acetonitrile: Methanol (70:30) was used as the mobile phase at a flow rate of 1.0 ml/min using a Symmetry C18 column Finepack SIL C18T-5 (250x4.6 mm, 5m). The effluent was spectroscopically monitored at 314 nm. The intraday and inter-day precisions showed coefficients of variation ranged from 0.62% to 2.78% at different levels of concentrations. The calibration curve was linear with a correlation coefficient of 0.9947. The averages of the absolute and relative recoveries were found to be 98.67% to 98.96%. The proposed HPLC method was successfully applied to quantify the amount of Febuxostat in bulk and dosage forms in quality control.

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2211429

  Paper ID - 228003

  Page Number(s) - d725-d732

  Pubished in - Volume 10 | Issue 11 | November 2022

  DOI (Digital Object Identifier) -   

  Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Cite this article

  Miss. Pragati Raju Kamble,  Miss. Nikita Vilas Pandagale,  Mr. Omkar D. Ghatage,  Mr. Pramod B. Patil,  Dr. S. V. Patil,   "DEVELOPMENT AND VALIDATION OF RP- HPLC METHOD FOR DETERMINATION OF FEBUXOSTAT IN BULK AND PHARMACEUTICAL DOSAGE FORM.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 11, pp.d725-d732, November 2022, Available at :http://www.ijcrt.org/papers/IJCRT2211429.pdf

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ISSN: 2320-2882
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Journal Starting Year (ESTD) : 2013
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ISSN and 7.97 Impact Factor Details


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ISSN
ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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