Published Paper Details:

The crucial factor that determines the acceptability of a medication and also the flexibility of its administration is its solubility. Significant portions of recently invented drugs are water insoluble, which makes them poorly bioavailable and limits continuous improvement. By combining these acknowledged rivals into Nanosuspension, they can now be conveyed. Nanosuspension invention addressed the issue of medications with poor water solubility and inadequate bioavailability. Using the Nanosuspension technology, The drugs' bioavailability and stabilization can be improved. All medications that are liquids insoluble can benefit from Nanosuspension treatment, which is inexpensive and effective. To create nanosuspensions, a wet mill, high strain homogenizer, melt emulsification method, emulsion solvent evaporation, and super significant fluid systems are utilised. It is possible to create nanosuspension using preservatives, both natural and organic solvents, and other substances such buffers, salts, polyols, osmogent, and cry protectant. Additionally possible methods for administering nanosuspensions include oral, parenteral, aspiratory, and ocular. Nanosuspensions can be employed for mucoadhesive hydrogels and targeted drug administration when used as ocular inserts. The main considerations for better use and scaling up of nanosuspensions include maintaining stability in solution and in the solid state and resuspendability without coalescence. The use of nanosuspensions in a variety of drug delivery methods, including transdermal, buccal, nasal, ocular, and oral is now also the topic of ongoing investigation. Oral drug delivery system of nanosuspension with a receptor mediated endocytosis, which is a desirable capability, can resolve the majority of permeability limiting absorption and associated challenges that adversely affect bioavailability. There are a number of formulation obstacles that protein- and peptide-based medications currently encounter that can be handled well with development of current digital era like Nanosuspension.