Published Paper Details:

Solubility, the phenomenon of dissolution of solute in a solvent in a specified condition to give a homogenous system, is the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. the primary aim of this review was to improve the solubility of BCS Class-II drugs because of their low solubility and dissolution rate. Therefore, the enhancement of solubility of practically insoluble drug was the most challenging aspect of drug development pharmaceutically active molecules with low solubility convey a higher risk of failure for drug innovation and development. pharmacokinetics, pharmacodynamics, and some other parameters, such as drug absorption, drug distribution, protein binding,etc. are majorly affected by their solubility. among all pharmaceutical dosage forms, oral dosage forms cover more than 50%, and the drug molecule should be water-soluble. for maintaining good therapeutic activity by the drug molecule on the target site, solubility and bioavailability are the major factors. hence with the advancement of chemical science, the need of development of pharmaceutical technologies to improve patient compliance for medication. This article aims is to describe the different solubility enhancement techniques to improve the solubility of the drug by different approaches such as traditional and Novel methods like pH adjustment, Micronization,homogenization, Salt formation, Lyophilization, hot melt Extrusion, Solvent evaporation, melt son crystallization, prodrug approach, etc. for the acquirement of the effective absorption and improved bioavailability.