Published Paper Details:

INTRODUCTION: The International Society on Thrombosis and Hemostasis gives the following definition for DIC: "An acquired syndrome characterized by the intravascular activation of coagulation with loss of localization arising from different causes. It can originate from and cause damage to the microvasculature, which if sufficiently severe can produce organ dysfunction". Disseminated intravascular coagulation (DIC) is a relatively commonly suspected complication in myriad clinical situations in hospital settings (ICU)1. METHOD: The present study "Differential diagnosis of Disseminated Intravascular Coagulation by hematological and coagulation tests" was conducted in our institution. Total 100 cases of patients admitted in ICU wards of Medicine, Pediatrics and Obstetrics and Gynecology were studied. RESULT: Hematological and coagulation profile in 100 cases of patients with thrombocytopenia, <150/cmm or >25% decrease from baseline were studied. Out of 100 cases 85 cases show coagulation disorder with DIC, 5 cases show normal coagulation profile with Hemolytic uremic syndrome - Thrombotic thrombocytopenic purpura (HUS-TTP), and remaining 10 cases were of only thrombocytopenia. CONCLUSION: D Dimer is >0.5 ug/dl in 100% of cases, so it can be used as more specific test when both platelet count and PT are deranged to confirm diagnosis of DIC. The combination of platelet count and PT help discriminate between TTP-HUS and DIC.