Published Paper Details:

? Abstract The adhesion between two materials, at least one of which is a mucosal surface, is generally referred to as mucoadhesion. Mucosal medication delivery has drawn a lot of interest during the past few decades. Mucoadhesive dosage forms may be created to provide a regulated rate of drug release for a better therapeutic result by enabling prolonged retention at the site of application. Drug molecules that are not suitable for oral administration, such as those that undergo acid degradation or substantial first-pass metabolism, may benefit from the application of dosage forms to mucosal surfaces. The nature of the mucosal tissue and the physicochemical characteristics of the polymeric formulation are just two examples of the many variables that affect a dosage form's capacity to adhere to mucous membranes. This review article seeks to give a general overview of the numerous mucoadhesion issues, Mucoadhesive materials, factors affecting mucoadhesion, evaluation techniques, and ultimately various Mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal). In the past 20 years, mucoadhesion has attracted fresh interest in drug delivery applications that involve extending the residence time of Mucoadhesive dose forms through various mucosal channels. Topical and local systems based on Mucoadhesive have demonstrated improved absorption. Since Mucoadhesive drug administration has a large surface area and a strong blood flow, it provides quick absorption and good bioavailability. Drug distribution over the mucosa avoids first-pass hepatic metabolism and gastrointestinal enzyme degradation. In order to distribute a rising number of high-molecular-weight sensitive compounds, such as peptide and oligonucleotides, mucosal drug delivery systems may be useful. The goal of this review is to provide a thorough explanation of mucoadhesion, most popular routes of administration for mucoadhesives along with oral and parenteral routes for minimisation of the nasal delivery by thermoreversible mucoadhesive.